Blended Wing Body (BWB) aircraft with around 1000 passengers and crew are being proposed by aircraft manufacturers. This type of aircraft configuration is radically different from conventional tube type passenger aircraft and so it is essential to explore issues related to both fire and evacuation for these configurations. Due to both the large size and the unusual nature of the cabin layouts, computer simulation provides the ideal method to explore these issues. In this paper we describe the application of both fire and evacuation simulation to BWB cabin configurations. The validity of the computer evacaution simulations is also explored through full-scale evacuation experiments.